Centrosomal protein 85

CEP85
Identifiers
Aliases	CEP85, CCDC21, centrosomal protein 85
External IDs	MGI: 1917262; HomoloGene: 11254; GeneCards: CEP85; OMA:CEP85 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 26,234,200 bp[1] End 26,278,808 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 134,129,858 bp[2] End 134,187,112 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte Skeletal muscle tissue of rectus abdominis muscle of thigh thoracic diaphragm gastrocnemius muscle apex of heart vastus lateralis muscle gonad muscle of arm Top expressed in right kidney spermatocyte muscle of thigh thymus neural layer of retina yolk sac proximal tubule otic vesicle zygote spermatid More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component centrosome Golgi apparatus spindle pole pericentriolar material nucleolus cytoskeleton nucleus cytoplasm cytosol mitochondrion microtubule organizing center Biological process regulation of mitotic centrosome separation negative regulation of protein kinase activity chromosome segregation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64793 70012 Ensembl ENSG00000130695 ENSMUSG00000037443 UniProt Q6P2H3 Q8BMK0 RefSeq (mRNA) NM_001281517 NM_001281518 NM_022778 NM_001319944 NM_144527 RefSeq (protein) NP_001268446 NP_001268447 NP_001306873 NP_073615 NP_653110 Location (UCSC) Chr 1: 26.23 – 26.28 Mb Chr 4: 134.13 – 134.19 Mb PubMed search [3] [4]
Wikidata
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Centrosomal protein 85 is a protein that in humans is encoded by the CEP85 gene. ^[5]

Function

This gene encodes a protein that belongs to the centrosome-associated family of proteins. The centrosome is a subcellular organelle in the animal cell that functions as a microtubule organizing center and is involved in cell-cycle progression. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013].

References

1. GRCh38: Ensembl release 89: ENSG00000130695 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000037443 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Centrosomal protein 85". Retrieved 2018-06-01.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.