Dishevelled binding antagonist of beta catenin 2

DACT2
Identifiers
Aliases	DACT2, C6orf116, DAPPER2, DPR2, bA503C24.7, dishevelled binding antagonist of beta catenin 2
External IDs	OMIM: 608966; MGI: 1920347; HomoloGene: 18237; GeneCards: DACT2; OMA:DACT2 - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	168,319,777 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	14,424,566 bp
RNA expression pattern
	Top expressed in
	placenta; ; testicle; ; putamen; ; nucleus accumbens; ; caudate nucleus; ; apex of heart; ; decidua; ; minor salivary glands; ; skin of leg; ; skin of abdomen;
	Top expressed in
	renal pelvis; ; midgut; ; umbilical vein; ; renal calyx; ; cervical loop; ; Hindgut; ; visual cortex; ; superior frontal gyrus; ; primary visual cortex; ; primary motor cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein kinase C binding; beta-catenin binding; transcription factor binding; protein kinase A binding; delta-catenin binding;
Cellular component	cytoplasm;
Biological process	regulation of Wnt signaling pathway; hematopoietic progenitor cell differentiation; epithelial cell morphogenesis; negative regulation of cell adhesion; skin development; inner medullary collecting duct development; negative regulation of nodal signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	168002
	240025
	ENSG00000164488
	ENSMUSG00000048826
	Q5SW24
	Q7TN08
	NM_001286350; NM_001286351; NM_214462
	NM_172826
	NP_001273279; NP_001273280; NP_999627
	NP_766414
	Wikidata
View/Edit Human	View/Edit Mouse

Protein found in humans

Dishevelled binding antagonist of beta catenin 2 is a protein that in humans is encoded by the DACT2 gene.^[5]

References

^ a b c GRCh38: Ensembl release 89: ENSG00000164488 – Ensembl, May 2017
^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048826 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: Dishevelled binding antagonist of beta catenin 2". Retrieved 2017-09-10.

Koga Y, Yao T, Hirahashi M, Kumashiro Y, Ohji Y, Yamada T, Tanaka M, Tsuneyoshi M (2008). "Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence". Histopathology. 52 (5): 569–77. doi:10.1111/j.1365-2559.2008.02996.x. PMID 18370954. S2CID 26122361.
Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR (2010). "Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score". Mol. Med. 16 (7–8): 247–53. doi:10.2119/molmed.2009.00159. PMC 2896464. PMID 20379614.
Hendrickson SL, Lautenberger JA, Chinn LW, Malasky M, Sezgin E, Kingsley LA, Goedert JJ, Kirk GD, Gomperts ED, Buchbinder SP, Troyer JL, O'Brien SJ (2010). "Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression". PLOS ONE. 5 (9) e12862. Bibcode:2010PLoSO...512862H. doi:10.1371/journal.pone.0012862. PMC 2943476. PMID 20877624.
Jia Y, Yang Y, Brock MV, Zhan Q, Herman JG, Guo M (2013). "Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer". J. Pathol. 230 (2): 194–204. doi:10.1002/path.4073. PMC 4061565. PMID 22806826.
Cheng H, Lu M, Mao LJ, Wang JQ, Li W, Wen RM, Chen JC (2012). "Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas". Asian Pac. J. Cancer Prev. 13 (10): 5069–74. doi:10.7314/apjcp.2012.13.10.5069. PMID 23244112.
Zhang X, Yang Y, Liu X, Herman JG, Brock MV, Licchesi JD, Yue W, Pei X, Guo M (2013). "Epigenetic regulation of the Wnt signaling inhibitor DACT2 in human hepatocellular carcinoma". Epigenetics. 8 (4): 373–82. doi:10.4161/epi.24113. PMC 3674046. PMID 23449122.
Gao S, Yang Z, Zheng ZY, Yao J, Zhang F, Wu LM, Xie HY, Zhou L, Zheng SS (2013). "Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing". World J Surg Oncol. 11: 57. doi:10.1186/1477-7819-11-57. PMC 3605395. PMID 23496880.
Hou J, Liao LD, Xie YM, Zeng FM, Ji X, Chen B, Li LY, Zhu MX, Yang CX, Qing-Zhao, Chen T, Xu XE, Shen J, Guo MZ, Li EM, Xu LY (2013). "DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma". Cancer Prev Res (Phila). 6 (8): 791–800. doi:10.1158/1940-6207.CAPR-12-0352. PMID 23803417.
Wang S, Dong Y, Zhang Y, Wang X, Xu L, Yang S, Li X, Dong H, Xu L, Su L, Ng SS, Chang Z, Sung JJ, Zhang X, Yu J (2015). "DACT2 is a functional tumor suppressor through inhibiting Wnt/β-catenin pathway and associated with poor survival in colon cancer". Oncogene. 34 (20): 2575–85. doi:10.1038/onc.2014.201. PMC 4761644. PMID 25023701.

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000164488 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000048826 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Dishevelled binding antagonist of beta catenin 2". Retrieved 2017-09-10.

Dishevelled binding antagonist of beta catenin 2

References

Further reading