ADGRL4

ADGRL4
Identifiers
Aliases	ADGRL4, ETL, KPG_003, ELTD1, adhesion G protein-coupled receptor L4
External IDs	OMIM: 616419; MGI: 2655562; HomoloGene: 11170; GeneCards: ADGRL4; OMA:ADGRL4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p31.1 Start 78,889,764 bp[1] End 79,282,124 bp[1]
Gene location (Mouse) Chr. Chromosome 3 (mouse)[2] Band 3|3 H3 Start 151,143,524 bp[2] End 151,250,723 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pericardium visceral pleura parietal pleura subcutaneous adipose tissue Achilles tendon smooth muscle tissue lower lobe of lung gallbladder vena cava mammary gland Top expressed in right lung zygote interventricular septum right lung lobe myocardium of ventricle soleus muscle brown adipose tissue right ventricle endothelial cell of lymphatic vessel right kidney More reference expression data BioGPS More reference expression data
Gene ontology Molecular function calcium ion binding G protein-coupled receptor activity protein dimerization activity transmembrane signaling receptor activity signal transducer activity Cellular component integral component of membrane plasma membrane cytoplasmic vesicle membrane integral component of plasma membrane Biological process G protein-coupled receptor signaling pathway cell surface receptor signaling pathway signal transduction adenylate cyclase-activating G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 64123 170757 Ensembl ENSG00000162618 ENSMUSG00000039167 UniProt Q9HBW9 Q923X1 RefSeq (mRNA) NM_022159 NM_133222 RefSeq (protein) NP_071442 NP_573485 Location (UCSC) Chr 1: 78.89 – 79.28 Mb Chr 3: 151.14 – 151.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Adhesion G protein-coupled receptor L4 is a latrophilin-like orphan receptor of the adhesion G protein-coupled receptor family. In humans this protein is encoded by the ADGRL4 gene.^[5][6] ADGRL4 appears to have a role in angiogenesis,^[7] both physiological and pathological in cancer.^[8]

See also

• Latrophilin

References

1. GRCh38: Ensembl release 89: ENSG00000162618 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000039167 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Nechiporuk T, Urness LD, Keating MT (February 2001). "ETL, a novel seven-transmembrane receptor that is developmentally regulated in the heart. ETL is a member of the secretin family and belongs to the epidermal growth factor-seven-transmembrane subfamily". The Journal of Biological Chemistry. 276 (6): 4150–7. doi:10.1074/jbc.M004814200. PMID 11050079.
6. "Entrez Gene: ELTD1 EGF, latrophilin and seven transmembrane domain containing 1".
7. Masiero M, Simões FC, Han HD, Snell C, Peterkin T, Bridges E, et al. (August 2013). "A core human primary tumor angiogenesis signature identifies the endothelial orphan receptor ELTD1 as a key regulator of angiogenesis". Cancer Cell. 24 (2): 229–41. doi:10.1016/j.ccr.2013.06.004. PMC 3743050. PMID 23871637.
8. Serban F, Artene SA, Georgescu AM, Purcaru SO, Tache DE, Alexandru O, Dricu A (December 2015). "Epidermal growth factor, latrophilin, and seven transmembrane domain-containing protein 1 marker, a novel angiogenesis marker". OncoTargets and Therapy. 8: 3767–74. doi:10.2147/OTT.S93843. PMC 4689259. PMID 26719704.

Further reading

• Bjarnadóttir TK, Fredriksson R, Höglund PJ, Gloriam DE, Lagerström MC, Schiöth HB (July 2004). "The human and mouse repertoire of the adhesion family of G-protein-coupled receptors". Genomics. 84 (1): 23–33. doi:10.1016/j.ygeno.2003.12.004. PMID 15203201.
• Liu T, Qian WJ, Gritsenko MA, Camp DG, Monroe ME, Moore RJ, Smith RD (2006). "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry". Journal of Proteome Research. 4 (6): 2070–80. doi:10.1021/pr0502065. PMC 1850943. PMID 16335952.
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.