Insulin like 6

INSL6
Identifiers
Aliases	INSL6, RIF1, insulin like 6
External IDs	OMIM: 606414; MGI: 1351595; HomoloGene: 5197; GeneCards: INSL6; OMA:INSL6 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p24.1 Start 5,123,880 bp[1] End 5,185,647 bp[1]
Gene location (Mouse) Chr. Chromosome 19 (mouse)[2] Band 19|19 C1 Start 29,298,744 bp[2] End 29,302,756 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle left testis right testis Achilles tendon gonad monocyte popliteal artery tibial arteries ascending aorta Descending thoracic aorta Top expressed in seminiferous tubule spermatocyte spermatid jejunum transitional epithelium of urinary bladder duodenum intestinal villus ileum right kidney embryo More reference expression data BioGPS n/a
Gene ontology Molecular function hormone activity Cellular component extracellular region cellular component Biological process regulation of signaling receptor activity biological process signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11172 27356 Ensembl ENSG00000120210 ENSMUSG00000050957 UniProt Q9Y581 Q9QY05 RefSeq (mRNA) NM_007179 NM_013754 RefSeq (protein) NP_009110 NP_038782 Location (UCSC) Chr 9: 5.12 – 5.19 Mb Chr 19: 29.3 – 29.3 Mb PubMed search [3] [4]
Wikidata
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Insulin like 6 is a protein that in humans is encoded by the INSL6 gene. ^[5]

Function

The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization.

References

1. GRCh38: Ensembl release 89: ENSG00000120210 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000050957 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Insulin like 6". Retrieved 2016-02-25.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.