Protein-coding gene in the species Homo sapiens
| ACOT12 |
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| Available structures |
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| PDB | Ortholog search: PDBe RCSB |
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| List of PDB id codes |
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3B7K, 4MOB, 4MOC |
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| Identifiers |
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| Aliases | ACOT12, CACH-1, Cach, STARD15, THEAL, acyl-CoA thioesterase 12 |
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| External IDs | OMIM: 614315; MGI: 1921406; HomoloGene: 12540; GeneCards: ACOT12; OMA:ACOT12 - orthologs |
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| Gene location (Mouse) |
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 | | Chr. | Chromosome 13 (mouse)[2] |
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| | Band | 13|13 C3 | Start | 91,889,631 bp[2] |
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| End | 91,934,267 bp[2] |
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| RNA expression pattern |
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| Bgee | | Human | Mouse (ortholog) |
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| Top expressed in | - right lobe of liver
- testicle
- buccal mucosa cell
- human kidney
- duodenum
- gonad
- Achilles tendon
- stromal cell of endometrium
- hypothalamus
- muscle tissue
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| | Top expressed in | - right kidney
- human kidney
- left lobe of liver
- proximal tubule
- jejunum
- intestinal villus
- duodenum
- seminiferous tubule
- epithelium of small intestine
- embryo
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| | More reference expression data |
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| BioGPS |  | | More reference expression data |
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| Gene ontology |
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| Molecular function |
- carboxylic ester hydrolase activity
- ATP binding
- hydrolase activity
- lipid binding
- acetyl-CoA hydrolase activity
- acyl-CoA hydrolase activity
- fatty-acyl-CoA binding
- palmitoyl-CoA hydrolase activity
- long-chain fatty acyl-CoA binding
- thiolester hydrolase activity
| | Cellular component | | | Biological process |
- pyruvate metabolic process
- lipid metabolism
- acyl-CoA metabolic process
- acetyl-CoA metabolic process
- fatty acid metabolic process
- palmitic acid biosynthetic process
| | Sources:Amigo / QuickGO |
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| Wikidata |
| View/Edit Human | View/Edit Mouse |
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Acyl-coenzyme A thioesterase 12 or StAR-related lipid transfer protein 15 (STARD15) is an enzyme that in humans is encoded by the ACOT12 gene.[5][6][7] The protein contains a StAR-related lipid transfer domain.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000172497 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021620 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
- ^ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
- ^ "Entrez Gene: ACOT12 acyl-CoA thioesterase 12".
External links
- Human ACOT12 genome location and ACOT12 gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Acetyl-coenzyme A thioesterase
Further reading
- Suematsu N, Isohashi F (2007). "Molecular cloning and functional expression of human cytosolic acetyl-CoA hydrolase". Acta Biochim. Pol. 53 (3): 553–61. doi:10.18388/abp.2006_3327. PMID 16951743.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Suematsu N, Okamoto K, Isohashi F (2004). "Simple and unique purification by size-exclusion chromatography for an oligomeric enzyme, rat liver cytosolic acetyl-coenzyme A hydrolase". J. Chromatogr. B. 790 (1–2): 239–44. doi:10.1016/s1570-0232(03)00167-3. PMID 12767336.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suematsu N, Okamoto K, Shibata K, et al. (2001). "Molecular cloning and functional expression of rat liver cytosolic acetyl-CoA hydrolase". Eur. J. Biochem. 268 (9): 2700–9. doi:10.1046/j.1432-1327.2001.02162.x. PMID 11322891.
