OSR2 (gene)

OSR2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2EE8
Identifiers
Aliases	OSR2, odd-skipped related transciption factor 2
External IDs	OMIM: 611297; MGI: 1930813; HomoloGene: 14200; GeneCards: OSR2; OMA:OSR2 - orthologs
Gene location (Human) Chr. Chromosome 8 (human)[1] Band 8q22.2 Start 98,944,403 bp[1] End 98,952,104 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 B3.1|15 14.46 cM Start 35,296,244 bp[2] End 35,303,451 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva body of uterus canal of the cervix left uterine tube seminal vesicula right ovary urethra decidua ectocervix right uterine tube Top expressed in genital tubercle female external genitalia uterus paramesonephric duct ileum intestinal villus vas deferens eyelid right kidney jejunum More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion binding protein binding nucleic acid binding sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific RNA polymerase II transcription regulatory region sequence-specific DNA binding Cellular component nucleus Biological process negative regulation of transcription by RNA polymerase II metanephros development mesonephros development chondrocyte differentiation positive regulation of cell population proliferation positive regulation of gene expression cell differentiation positive regulation of bone mineralization osteoblast proliferation embryonic forelimb morphogenesis embryonic hindlimb morphogenesis embryonic skeletal limb joint morphogenesis middle ear morphogenesis odontogenesis embryonic digit morphogenesis positive regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II embryonic skeletal system morphogenesis positive regulation of epithelial cell proliferation roof of mouth development embryonic skeletal joint morphogenesis head development bone morphogenesis eyelid development in camera-type eye embryonic skeletal joint development embryo development ending in birth or egg hatching urogenital system development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116039 107587 Ensembl ENSG00000164920 ENSMUSG00000022330 UniProt Q8N2R0 Q91ZD1 RefSeq (mRNA) NM_001142462 NM_001286841 NM_053001 NM_001394683 NM_054049 NM_001368665 RefSeq (protein) NP_001135934 NP_001273770 NP_443727 NP_473390 NP_001355594 Location (UCSC) Chr 8: 98.94 – 98.95 Mb Chr 15: 35.3 – 35.3 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein odd-skipped-related 2 is a protein that in humans is encoded by the OSR2 gene.^[5] In mice, it is involved in the development of the palate and in suppressing the formation of teeth after the eruption of adult teeth.

References

1. GRCh38: Ensembl release 89: ENSG00000164920 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000022330 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: OSR2 odd-skipped related 2 (Drosophila)".

Further reading

• Kawai S, Kato T, Inaba H, Okahashi N, Amano A (2005). "Odd-skipped related 2 splicing variants show opposite transcriptional activity". Biochem. Biophys. Res. Commun. 328 (1): 306–11. doi:10.1016/j.bbrc.2004.12.173. PMID 15670784.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Lan Y, Ovitt CE, Cho ES, Maltby KM, Wang Q, Jiang R (2004). "Odd-skipped related 2 (Osr2) encodes a key intrinsic regulator of secondary palate growth and morphogenesis". Development. 131 (13): 3207–16. doi:10.1242/dev.01175. PMID 15175245. S2CID 17503942.
• Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Katoh M (2003). "Molecular cloning and characterization of OSR1 on human chromosome 2p24". Int. J. Mol. Med. 10 (2): 221–5. doi:10.3892/ijmm.10.2.221. PMID 12119563.
• Lan Y, Kingsley PD, Cho ES, Jiang R (2001). "Osr2, a new mouse gene related to Drosophila odd-skipped, exhibits dynamic expression patterns during craniofacial, limb, and kidney development". Mech. Dev. 107 (1–2): 175–9. doi:10.1016/S0925-4773(01)00457-9. PMID 11520675. S2CID 14286470.

See also

OSR1