SEPT14

SEPTIN14
Identifiers
Aliases	SEPTIN14, septin 14, SEPT14
External IDs	OMIM: 612140; MGI: 1921472; HomoloGene: 87501; GeneCards: SEPTIN14; OMA:SEPTIN14 - orthologs
Gene location (Human) Chr. Chromosome 7 (human)[1] Band 7p11.2 Start 55,793,540 bp[1] End 55,862,755 bp[1]
Gene location (Mouse) Chr. Chromosome 5 (mouse)[2] Band 5|5 G1.3 Start 129,760,455 bp[2] End 129,785,576 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right testis left testis gonad testicle blood monocyte endometrium anterior pituitary right lobe of liver spleen Top expressed in zygote spermatocyte secondary oocyte spermatid primary oocyte testicle More reference expression data BioGPS n/a
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity molecular adaptor activity Cellular component cytoplasm cytoskeleton septin ring microtubule cytoskeleton septin complex septin filament array Biological process cell cycle cell division mitotic cytokinesis septin ring assembly cilium assembly cytoskeleton-dependent cytokinesis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 346288 74222 Ensembl ENSG00000154997 ENSMUSG00000034219 UniProt Q6ZU15 Q9DA97 RefSeq (mRNA) NM_207366 NM_028826 RefSeq (protein) NP_997249 NP_083102 Location (UCSC) Chr 7: 55.79 – 55.86 Mb Chr 5: 129.76 – 129.79 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Septin 14 is a protein that in humans is encoded by the SEPT14 gene.^[5]

Function

SEPT14 is a member of the highly conserved septin family of GTP-binding cytoskeletal proteins implicated in membrane transport, apoptosis, cell polarity, cell cycle regulation, cytokinesis, and other cellular functions.

References

1. GRCh38: Ensembl release 89: ENSG00000154997 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034219 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Septin 14".

Further reading

• Peterson EA, Kalikin LM, Steels JD, Estey MP, Trimble WS, Petty EM (November 2007). "Characterization of a SEPT9 interacting protein, SEPT14, a novel testis-specific septin". Mammalian Genome. 18 (11): 796–807. doi:10.1007/s00335-007-9065-x. PMID 17922164. S2CID 9906543.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.