SEC24A

SEC24A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2NUP, 2NUT, 3EGD, 3EGX
Identifiers
Aliases	SEC24A, SEC24 homolog A, COPII coat complex component
External IDs	OMIM: 607183; MGI: 1924621; HomoloGene: 70131; GeneCards: SEC24A; OMA:SEC24A - orthologs
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q31.1 Start 134,648,785 bp[1] End 134,727,909 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 51,583,091 bp[2] End 51,654,461 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa mucosa of sigmoid colon oocyte cartilage tissue parotid gland oral cavity secondary oocyte Epithelium of choroid plexus tail of epididymis tibia Top expressed in epithelium of small intestine seminal vesicula left lobe of liver migratory enteric neural crest cell salivary gland lacrimal gland submandibular gland body of femur lobe of prostate cumulus cell More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding zinc ion binding metal ion binding Cellular component cytoplasm endoplasmic reticulum membrane membrane Golgi membrane endoplasmic reticulum COPII vesicle coat cytosol ER to Golgi transport vesicle membrane cytoplasmic vesicle Biological process antigen processing and presentation of exogenous peptide antigen via MHC class II antigen processing and presentation of peptide antigen via MHC class I COPII vesicle coating positive regulation of protein secretion protein transport intracellular protein transport vesicle-mediated transport endoplasmic reticulum to Golgi vesicle-mediated transport COPII-coated vesicle cargo loading cholesterol homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10802 77371 Ensembl ENSG00000113615 ENSMUSG00000036391 UniProt O95486 Q3U2P1 RefSeq (mRNA) NM_001252231 NM_021982 NM_001290785 NM_175255 RefSeq (protein) NP_001239160 NP_068817 NP_001277714 NP_780464 Location (UCSC) Chr 5: 134.65 – 134.73 Mb Chr 11: 51.58 – 51.65 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

SEC24 family, member A (S. cerevisiae) is a protein that in humans is encoded by the SEC24A gene.^[5] The protein belongs to a protein family that are homologous to yeast Sec24.^[6] It is a component of coat protein II (COPII)-coated vesicles that mediate protein transport from the endoplasmic reticulum.^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000113615 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000036391 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "SEC24 family, member A (S. cerevisiae)". Retrieved 2011-12-05.
6. Tang BL, Kausalya J, Low DY, Lock ML, Hong W (May 1999). "A family of mammalian proteins homologous to yeast Sec24p". Biochemical and Biophysical Research Communications. 258 (3): 679–84. Bibcode:1999BBRC..258..679T. doi:10.1006/bbrc.1999.0574. PMID 10329445.

Further reading

• Mancias JD, Goldberg J (May 2007). "The transport signal on Sec22 for packaging into COPII-coated vesicles is a conformational epitope". Molecular Cell. 26 (3): 403–14. doi:10.1016/j.molcel.2007.03.017. PMID 17499046.
• Wendeler MW, Paccaud JP, Hauri HP (March 2007). "Role of Sec24 isoforms in selective export of membrane proteins from the endoplasmic reticulum". EMBO Reports. 8 (3): 258–64. doi:10.1038/sj.embor.7400893. PMC 1808030. PMID 17255961.
• Kirchhausen T (December 2000). "Three ways to make a vesicle". Nature Reviews. Molecular Cell Biology. 1 (3): 187–98. doi:10.1038/35043117. PMID 11252894. S2CID 205011168.

External links

• PDBe-KB provides an overview of all the structure information available in the PDB for Human Protein transport protein Sec24A