Tweety family member 2

TTYH2
Identifiers
Aliases	TTYH2, C17orf29, Tweety family member 2
External IDs	OMIM: 608855; MGI: 2157091; HomoloGene: 41882; GeneCards: TTYH2; OMA:TTYH2 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17q25.1 Start 74,213,571 bp[1] End 74,262,020 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 E2 Start 114,566,257 bp[2] End 114,611,803 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in inferior ganglion of vagus nerve external globus pallidus corpus callosum subthalamic nucleus pars reticulata medulla oblongata ventral tegmental area pars compacta pons superior vestibular nucleus Top expressed in lumbar subsegment of spinal cord left lobe of liver internal carotid artery external carotid artery blastocyst intestinal villus motor neuron duodenum jejunum pineal gland More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding chloride channel activity intracellular calcium activated chloride channel activity volume-sensitive chloride channel activity Cellular component integral component of membrane plasma membrane membrane chloride channel complex Biological process chloride transport chloride transmembrane transport ion transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 94015 117160 Ensembl ENSG00000141540 ENSMUSG00000034714 UniProt Q9BSA4 Q3TH73 RefSeq (mRNA) NM_032646 NM_052869 NM_001330453 NM_053273 RefSeq (protein) NP_001317382 NP_116035 NP_443101 NP_444503 Location (UCSC) Chr 17: 74.21 – 74.26 Mb Chr 11: 114.57 – 114.61 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tweety family member 2 is a protein that in humans is encoded by the TTYH2 gene.^[5] Members of this family function as chloride channels. The encoded protein functions as a calcium²⁺-activated large conductance chloride(-) channel, and may play a role in kidney tumorigenesis. Two transcript variants encoding distinct isoforms have been identified for this gene.

See also

• Tweety family member 3 (TTYH3)

References

1. GRCh38: Ensembl release 89: ENSG00000141540 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000034714 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: Tweety family member 2".

Further reading

• Bisson N, James DA, Ivosev G, Tate SA, Bonner R, Taylor L, Pawson T (June 2011). "Selected reaction monitoring mass spectrometry reveals the dynamics of signaling through the GRB2 adaptor". Nature Biotechnology. 29 (7): 653–8. doi:10.1038/nbt.1905. PMID 21706016. S2CID 205275786.
• Ibarrola N, Molina H, Iwahori A, Pandey A (April 2004). "A novel proteomic approach for specific identification of tyrosine kinase substrates using [13C]tyrosine". The Journal of Biological Chemistry. 279 (16): 15805–13. doi:10.1074/jbc.M311714200. PMID 14739304.
• Rae FK, Hooper JD, Eyre HJ, Sutherland GR, Nicol DL, Clements JA (October 2001). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is located on 17q24 and upregulated in renal cell carcinoma". Genomics. 77 (3): 200–7. doi:10.1006/geno.2001.6629. PMID 11597145.
• Toiyama Y, Mizoguchi A, Kimura K, Hiro J, Inoue Y, Tutumi T, Miki C, Kusunoki M (May 2007). "TTYH2, a human homologue of the Drosophila melanogaster gene tweety, is up-regulated in colon carcinoma and involved in cell proliferation and cell aggregation". World Journal of Gastroenterology. 13 (19): 2717–21. doi:10.3748/wjg.v13.i19.2717. PMC 4147121. PMID 17569141.
• Suzuki M, Mizuno A (May 2004). "A novel human Cl(-) channel family related to Drosophila flightless locus". The Journal of Biological Chemistry. 279 (21): 22461–8. doi:10.1074/jbc.M313813200. PMID 15010458.
• He Y, Ramsay AJ, Hunt ML, Whitbread AK, Myers SA, Hooper JD (May 2008). "N-glycosylation analysis of the human Tweety family of putative chloride ion channels supports a penta-spanning membrane arrangement: impact of N-glycosylation on cellular processing of Tweety homologue 2 (TTYH2)". The Biochemical Journal. 412 (1): 45–55. doi:10.1042/BJ20071722. PMID 18260827. S2CID 25166381.
• He Y, Hryciw DH, Carroll ML, Myers SA, Whitbread AK, Kumar S, Poronnik P, Hooper JD (August 2008). "The ubiquitin-protein ligase Nedd4-2 differentially interacts with and regulates members of the Tweety family of chloride ion channels". The Journal of Biological Chemistry. 283 (35): 24000–10. doi:10.1074/jbc.M803361200. PMC 3259790. PMID 18577513.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.