Zinc transporter ZIP3

SLC39A3
Identifiers
Aliases	SLC39A3, ZIP-3, ZIP3, solute carrier family 39 member 3
External IDs	OMIM: 612168; MGI: 2147269; HomoloGene: 44230; GeneCards: SLC39A3; OMA:SLC39A3 - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19p13.3 Start 2,732,204 bp[1] End 2,740,028 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 80,864,372 bp[2] End 80,873,260 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left testis right testis stromal cell of endometrium prefrontal cortex apex of heart islet of Langerhans smooth muscle tissue Brodmann area 9 monocyte cingulate gyrus Top expressed in neural layer of retina spermatocyte dentate gyrus of hippocampal formation granule cell superior frontal gyrus primary visual cortex subiculum olfactory tubercle cerebellar cortex medial dorsal nucleus lateral geniculate nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function metal ion transmembrane transporter activity zinc ion transmembrane transporter activity Cellular component integral component of membrane plasma membrane membrane Biological process metal ion transport zinc ion transport ion transport transmembrane transport cell morphogenesis in utero embryonic development T cell homeostasis embryonic cranial skeleton morphogenesis limb development zinc ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 29985 106947 Ensembl ENSG00000141873 ENSMUSG00000046822 UniProt Q9BRY0 Q99K24 RefSeq (mRNA) NM_213568 NM_144564 NM_134135 NM_001358898 RefSeq (protein) NP_653165 NP_998733 NP_598896 NP_001345827 Location (UCSC) Chr 19: 2.73 – 2.74 Mb Chr 10: 80.86 – 80.87 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Zinc transporter ZIP3 is a protein that in humans is encoded by the SLC39A3 gene.^[5][6]

See also

• Solute carrier family

References

1. GRCh38: Ensembl release 89: ENSG00000141873 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000046822 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Gaither LA, Eide DJ (February 2000). "Functional expression of the human hZIP2 zinc transporter". The Journal of Biological Chemistry. 275 (8): 5560–4. doi:10.1074/jbc.275.8.5560. PMID 10681536.
6. "Entrez Gene: SLC39A3 solute carrier family 39 (zinc transporter), member 3".

Further reading

• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Croci C, Brändstatter JH, Enz R (February 2003). "ZIP3, a new splice variant of the PKC-zeta-interacting protein family, binds to GABAC receptors, PKC-zeta, and Kv beta 2". The Journal of Biological Chemistry. 278 (8): 6128–35. doi:10.1074/jbc.M205162200. PMID 12431995.
• Dufner-Beattie J, Langmade SJ, Wang F, Eide D, Andrews GK (December 2003). "Structure, function, and regulation of a subfamily of mouse zinc transporter genes". The Journal of Biological Chemistry. 278 (50): 50142–50. doi:10.1074/jbc.M304163200. PMID 14525987.
• Wang F, Dufner-Beattie J, Kim BE, Petris MJ, Andrews G, Eide DJ (June 2004). "Zinc-stimulated endocytosis controls activity of the mouse ZIP1 and ZIP3 zinc uptake transporters". The Journal of Biological Chemistry. 279 (23): 24631–9. doi:10.1074/jbc.M400680200. PMID 15054103.
• Desouki MM, Geradts J, Milon B, Franklin RB, Costello LC (June 2007). "hZip2 and hZip3 zinc transporters are down regulated in human prostate adenocarcinomatous glands". Molecular Cancer. 6 37. doi:10.1186/1476-4598-6-37. PMC 1892035. PMID 17550612.