Sulfamation

In organic chemistry sulfamation is the installation of either of two related functional groups, sulfamic acid (R₂NSO₃H) and sulfamate (R₂NSO₃⁻). Typical methods entail reaction of primary amines with sources of sulfur trioxide such as pyridine-sulfur trioxide:^[1]

RNH₂ + SO₃ → RNHSO₃H

Sulfamation can also be effected by treating the amine with the sulfate ester of catechol (C₆H₄O₂SO₂).

References

1. DuBois, Grant E.; Stephenson, Rebecca A. (1980). 「スルホニルアミンを介したアミンのスルファム化．スルファミン酸塩の温和で高収率な合成」. The Journal of Organic Chemistry . 45 (26): 5371– 5373. doi :10.1021/jo01314a033.