CIAPIN1

CIAPIN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LD4, 2YUI, 4M7R
Identifiers
Aliases	CIAPIN1, 2810413N20Rik, Anamorsin, DRE2, PRO0915, cytokine induced apoptosis inhibitor 1, CIAE2
External IDs	OMIM: 608943; MGI: 1922083; HomoloGene: 10658; GeneCards: CIAPIN1; OMA:CIAPIN1 - orthologs
Gene location (Human) Chr. Chromosome 16 (human)[1] Band 16q21 Start 57,428,187 bp[1] End 57,447,420 bp[1]
Gene location (Mouse) Chr. Chromosome 8 (mouse)[2] Band 8|8 C5 Start 95,546,432 bp[2] End 95,564,986 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte left testis right testis sperm mucosa of transverse colon right adrenal cortex embryo apex of heart ganglionic eminence Top expressed in otic placode saccule spermatocyte spermatid yolk sac primitive streak facial motor nucleus fetal liver hematopoietic progenitor cell neural tube embryo More reference expression data BioGPS n/a
Gene ontology Molecular function methyltransferase activity iron-sulfur cluster binding protein binding metal ion binding 2 iron, 2 sulfur cluster binding 4 iron, 4 sulfur cluster binding electron transfer activity Cellular component cytoplasm mitochondrial intermembrane space nucleolus nucleus nucleoplasm mitochondrion Biological process methylation metabolism negative regulation of apoptotic process iron-sulfur cluster assembly apoptotic process hemopoiesis electron transport chain Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 57019 109006 Ensembl ENSG00000005194 ENSMUSG00000031781 UniProt Q6FI81 Q8WTY4 RefSeq (mRNA) NM_001308347 NM_001308358 NM_020313 NM_134141 RefSeq (protein) NP_001295276 NP_001295287 NP_064709 NP_598902 Location (UCSC) Chr 16: 57.43 – 57.45 Mb Chr 8: 95.55 – 95.56 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Anamorsin is a protein that in humans is encoded by the CIAPIN1 gene.^[5][6][7]

CIAPIN1 is a cytokine-induced inhibitor of apoptosis with no relation to apoptosis regulatory molecules of the BCL2 (MIM 151430) or CASP (see MIM 147678) families. Expression of CIAPIN1 is dependent on growth factor stimulation (Shibayama et al., 2004).[supplied by OMIM]^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000005194 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031781 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Loftus BJ, Kim UJ, Sneddon VP, Kalush F, Brandon R, Fuhrmann J, Mason T, Crosby ML, Barnstead M, Cronin L, Deslattes Mays A, Cao Y, Xu RX, Kang HL, Mitchell S, Eichler EE, Harris PC, Venter JC, Adams MD (Nov 1999). "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics. 60 (3): 295–308. doi:10.1006/geno.1999.5927. PMID 10493829.
6. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
7. "Entrez Gene: CIAPIN1 cytokine induced apoptosis inhibitor 1".

External links

• Human CIAPIN1 genome location and CIAPIN1 gene details page in the UCSC Genome Browser.

Further reading

• Hartley JL, Temple GF, Brasch MA (2001). "DNA Cloning Using In Vitro Site-Specific Recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Shibayama H, Takai E, Matsumura I, et al. (2004). "Identification of a Cytokine-induced Antiapoptotic Molecule Anamorsin Essential for Definitive Hematopoiesis". J. Exp. Med. 199 (4): 581–92. doi:10.1084/jem.20031858. PMC 2211823. PMID 14970183.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to Biology: A Functional Genomics Pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.
• Hao Z, Li X, Qiao T, et al. (2006). "CIAPIN1 confers multidrug resistance by upregulating the expression of MDR-1 and MRP-1 in gastric cancer cells". Cancer Biol. Ther. 5 (3): 261–6. doi:10.4161/cbt.5.3.2381. PMID 16410721.
• Hao Z, Li X, Qiao T, et al. (2007). "Subcellular localization of CIAPIN1". J. Histochem. Cytochem. 54 (12): 1437–44. doi:10.1369/jhc.6A6960.2006. PMC 3958118. PMID 16957168.