Derlin-3

DERL3
Identifiers
Aliases	DERL3, C22orf14, IZP6, LLN2, derlin-3, derlin 3
External IDs	OMIM: 610305; MGI: 1917627; HomoloGene: 41566; GeneCards: DERL3; OMA:DERL3 - orthologs
Gene location (Human) Chr. Chromosome 22 (human)[1] Band 22q11.23 Start 23,834,503 bp[1] End 23,839,128 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 C1 Start 75,893,413 bp[2] End 75,895,941 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow cell duodenum tonsil epithelium of colon appendix body of pancreas lymph node spleen mucosa of transverse colon rectum Top expressed in salivary gland submandibular gland lacrimal gland parotid gland zygote seminal vesicula primary oocyte secondary oocyte pyloric antrum epithelium of stomach More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding Cellular component integral component of membrane integral component of endoplasmic reticulum membrane endoplasmic reticulum endoplasmic reticulum membrane membrane signal recognition particle receptor complex signal recognition particle Biological process endoplasmic reticulum unfolded protein response negative regulation of retrograde protein transport, ER to cytosol protein N-linked glycosylation via asparagine ubiquitin-dependent ERAD pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 91319 70377 Ensembl ENSG00000274437 ENSG00000099958 ENSMUSG00000009092 UniProt Q96Q80 Q9D8K3 RefSeq (mRNA) NM_001002862 NM_001135751 NM_198440 NM_001363072 NM_024440 RefSeq (protein) NP_001002862 NP_001129223 NP_940842 NP_001350001 NP_077760 NP_001345912 NP_001345913 NP_001345914 Location (UCSC) Chr 22: 23.83 – 23.84 Mb Chr 10: 75.89 – 75.9 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Derlin-3 is a protein that in humans is encoded by the DERL3 gene.^[5][6]

See also

• Derlin-1
• Derlin-2

References

1. ENSG00000099958 GRCh38: Ensembl release 89: ENSG00000274437, ENSG00000099958 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000009092 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Lilley BN, Ploegh HL (Jun 2004). "A membrane protein required for dislocation of misfolded proteins from the ER". Nature. 429 (6994): 834–40. Bibcode:2004Natur.429..834L. doi:10.1038/nature02592. PMID 15215855. S2CID 29483256.
6. "Entrez Gene: DERL3 Der1-like domain family, member 3".

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Collins JE, Wright CL, Edwards CA, et al. (2005). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biol. 5 (10): R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Oda Y, Okada T, Yoshida H, et al. (2006). "Derlin-2 and Derlin-3 are regulated by the mammalian unfolded protein response and are required for ER-associated degradation". J. Cell Biol. 172 (3): 383–93. doi:10.1083/jcb.200507057. PMC 2063648. PMID 16449189.
• Wang X, Bolotin D, Chu DH, et al. (2006). "AP-2alpha: a regulator of EGF receptor signaling and proliferation in skin epidermis". J. Cell Biol. 172 (3): 409–21. doi:10.1083/jcb.200510002. PMC 2063650. PMID 16449191.
• Morrison JI, Lööf S, He P, Simon A (2006). "Salamander limb regeneration involves the activation of a multipotent skeletal muscle satellite cell population". J. Cell Biol. 172 (3): 433–40. doi:10.1083/jcb.200509011. PMC 2063652. PMID 16449193.