GUK1

GUK1
Identifiers
Aliases	GUK1, GMK, guanylate kinase 1
External IDs	OMIM: 139270; MGI: 95871; HomoloGene: 665; GeneCards: GUK1; OMA:GUK1 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1q42.13 Start 228,139,962 bp[1] End 228,148,984 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11|11 B1.3 Start 59,074,701 bp[2] End 59,083,038 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right frontal lobe prefrontal cortex amygdala C1 segment skin of leg skin of abdomen nucleus accumbens right lung caudate nucleus ascending aorta Top expressed in neural layer of retina facial motor nucleus dentate gyrus of hippocampal formation granule cell right kidney islet of Langerhans epithelium of lens esophagus superior frontal gyrus anterior horn of spinal cord embryo More reference expression data BioGPS n/a
Gene ontology Molecular function ATP binding kinase activity nucleotide binding transferase activity guanylate kinase activity Cellular component cytosol Biological process dGMP metabolic process purine nucleotide metabolic process nucleobase-containing small molecule interconversion glycoprotein transport GMP metabolic process ATP metabolic process nucleotide phosphorylation GDP biosynthetic process dGDP biosynthetic process dATP metabolic process phosphorylation GDP-mannose metabolic process GDP metabolic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2987 14923 Ensembl ENSG00000143774 ENSMUSG00000020444 UniProt Q16774 Q6IBG8 Q64520 RefSeq (mRNA) NM_000858 NM_001159390 NM_001159391 NM_001242839 NM_001242840 NM_001159410 NM_008193 RefSeq (protein) NP_000849 NP_001152862 NP_001152863 NP_001229768 NP_001229769 NP_000849.1 NP_001152862.1 NP_001152863.1 NP_001229768.1 NP_001152882 NP_032219 NP_001390762 NP_001390763 NP_001390764 NP_001390765 NP_001390766 Location (UCSC) Chr 1: 228.14 – 228.15 Mb Chr 11: 59.07 – 59.08 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Guanylate kinase is an enzyme that in humans is encoded by the GUK1 gene.^[5][6]

References

1. GRCh38: Ensembl release 89: ENSG00000143774 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000020444 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Fitzgibbon J, Katsanis N, Wells D, Delhanty J, Vallins W, Hunt DM (Jul 1996). "Human guanylate kinase (GUK1): cDNA sequence, expression and chromosomal localisation". FEBS Lett. 385 (3): 185–188. Bibcode:1996FEBSL.385..185F. doi:10.1016/0014-5793(96)00365-1. PMID 8647247.
6. "Entrez Gene: GUK1 guanylate kinase 1".

Further reading

• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Brady WA, Kokoris MS, Fitzgibbon M, Black ME (1996). "Cloning, characterization, and modeling of mouse and human guanylate kinases". J. Biol. Chem. 271 (28): 16734–16740. doi:10.1074/jbc.271.28.16734. PMID 8663313.
• Boritzki TJ, Jackson RC, Morris HP, Weber G (1981). "Guanosine-5'-phosphate synthetase and guanosine-5'-phosphate kinase in rat hepatomas and kidney tumors". Biochim. Biophys. Acta. 658 (1): 102–110. doi:10.1016/0005-2744(81)90253-9. PMID 6260205.
• Dallapiccola B, Lungarotti MS, Falorni A, Magnani M, Dacha M (1980). "Evidence for the assignment of GUK 1 gene locus to 1q32 leads to q43 segment from gene dosage effect". Ann. Genet. 23 (2): 83–85. PMID 6249178.
• Savitskiĭ IV (1990). "[Increase in 5'-nucleotidase and decrease in guanylate kinase activity in the brain and liver of irradiated rats]". Ukr. Biokhim. Zh. 62 (2): 110–114. PMID 2164269.
• Agarwal KC, Miech RP, Parks RE (1978). "Guanylate kinases from human erythrocytes, hog brain, and rat liver". Purine and Pyrimidine Nucleotide Metabolism. Methods in Enzymology. Vol. 51. pp. 483–490. doi:10.1016/S0076-6879(78)51066-5. ISBN 978-0-12-181951-4. PMID 211390.

External links

• Overview of all the structural information available in the PDB for UniProt: Q16774 (Human Guanylate kinase) at the PDBe-KB.
• Overview of all the structural information available in the PDB for UniProt: Q64520 (Mouse Guanylate kinase) at the PDBe-KB.