H antigen can refer to one of the various types of antigens having diverse biological functions:
- Also known as substance H, H antigen is a precursor to each of the ABO blood group antigens, apparently present in all people except those with the Bombay Blood phenotype[1] (see hh blood group). The gene responsible for making H antigen is FUT1, located on the 19th chromosome in humans.
- Histocompatibility antigen, a major factor in graft rejection.
- major H antigens (major histocompatibility antigen[2]) "encode molecules that present foreign peptides to T cells"[3][page needed]
- minor H antigens are polymorphic alloantigens presented on foreign major histocompatibility complex molecules.[3]: 525–526 Includes, e.g. the H-Y antigen. Even when major histocompatibility complex genotype is perfectly matched, can cause slow rejection of a graft.[3]: 525–526
- a bacterial flagellar antigen[4]
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References
- ^ Science Of Biogenetics (18 December 2023). "Do you Know Bombay Blood Group".
- ^ Doherty, P.C.; Zinkernagel, R.M. (1975). "A Biological Role for the Major Histocompatibility Antigens". The Lancet. 305 (7922): 1406–1609. doi:10.1016/s0140-6736(75)92610-0. PMID 49564.
- ^ a b c Janeway, Charles A. (2001). Immunobiology the immune system health & disease (5. ed.). New York: Garland. ISBN 978-0-8153-3642-6. Retrieved 16 December 2013.
- ^ Farlex. "antigen". The Free Dictionary. Retrieved 16 December 2013.
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