SOX15

SOX15
Identifiers
Aliases	SOX15, SOX20, SOX26, SOX27, SRY-box 15, SRY-box transcription factor 15
External IDs	OMIM: 601297; MGI: 98363; HomoloGene: 74586; GeneCards: SOX15; OMA:SOX15 - orthologs
Gene location (Human) Chr. Chromosome 17 (human)[1] Band 17p13.1 Start 7,588,178 bp[1] End 7,590,094 bp[1]
Gene location (Mouse) Chr. Chromosome 11 (mouse)[2] Band 11 B3|11 42.86 cM Start 69,546,140 bp[2] End 69,547,553 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte skin of abdomen skin of leg mucosa of pharynx vagina right hemisphere of cerebellum olfactory zone of nasal mucosa gonad epithelium of esophagus Top expressed in morula blastocyst morula corneal stroma transitional epithelium of urinary bladder lip secondary oocyte zygote esophagus entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity chromatin binding protein binding protein heterodimerization activity DNA-binding transcription factor activity, RNA polymerase II-specific DNA-binding transcription activator activity, RNA polymerase II-specific Cellular component cytoplasm nucleus Biological process positive regulation of myoblast proliferation cell differentiation male gonad development regulation of transcription, DNA-templated positive regulation of satellite cell activation involved in skeletal muscle regeneration negative regulation of striated muscle tissue development regulation of transcription by RNA polymerase II positive regulation of G0 to G1 transition negative regulation of transcription by RNA polymerase II chromatin organization myoblast development skeletal muscle tissue regeneration positive regulation of transcription by RNA polymerase II central nervous system development neuron differentiation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6665 20670 Ensembl ENSG00000129194 ENSMUSG00000041287 UniProt O60248 P43267 RefSeq (mRNA) NM_006942 NM_009235 RefSeq (protein) NP_008873 NP_033261 Location (UCSC) Chr 17: 7.59 – 7.59 Mb Chr 11: 69.55 – 69.55 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Protein SOX-15 is a protein that in humans is encoded by the SOX15 gene.^[5][6][7]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins.^[7]

See also

• SOX genes

References

1. GRCh38: Ensembl release 89: ENSG00000129194 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000041287 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Meyer J, Wirth J, Held M, Schempp W, Scherer G (Jan 1997). "SOX20, a new member of the SOX gene family, is located on chromosome 17p13". Cytogenet Cell Genet. 72 (2–3): 246–9. doi:10.1159/000134200. PMID 8978787.
6. Critcher R, Stitson RN, Wade-Martins R, Easty DJ, Farr CJ (Oct 1998). "Assignment of Sox4 to mouse chromosome 13 bands A3-A5 by fluorescence in situ hybridization; refinement of the human SOX4 location to 6p22.3 and of SOX20 to chromosome 17p12.3". Cytogenet Cell Genet. 81 (3–4): 294–5. doi:10.1159/000015052. PMID 9730625. S2CID 46849443.
7. "Entrez Gene: SOX15 SRY (sex determining region Y)-box 15".

Further reading

• Wilson M, Koopman P (2003). "Matching SOX: partner proteins and co-factors of the SOX family of transcriptional regulators". Curr. Opin. Genet. Dev. 12 (4): 441–6. doi:10.1016/S0959-437X(02)00323-4. PMID 12100890.
• Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families". Dev. Cell. 3 (2): 167–70. doi:10.1016/S1534-5807(02)00223-X. PMID 12194848.
• Gozé C, Poulat F, Berta P (1993). "Partial cloning of SOX-11 and SOX-12, two new human SOX genes". Nucleic Acids Res. 21 (12): 2943. doi:10.1093/nar/21.12.2943. PMC 309692. PMID 8332506.
• Hiraoka Y, Ogawa M, Sakai Y, et al. (1998). "Isolation and expression of a human SRY-related cDNA hSOX20". Biochim. Biophys. Acta. 1396 (2): 132–7. doi:10.1016/s0167-4781(97)00186-3. PMID 9540826.
• Cremazy F, Soullier S, Berta P, Jay P (1998). "Further complexity of the human SOX gene family revealed by the combined use of highly degenerate primers and nested PCR". FEBS Lett. 438 (3): 311–4. Bibcode:1998FEBSL.438..311C. doi:10.1016/S0014-5793(98)01294-0. PMID 9827568. S2CID 551497.
• Vujić M, Rajić T, Goodfellow PN, Stevanović M (1999). "cDNA characterization and high resolution mapping of the human SOX20 gene". Mamm. Genome. 9 (12): 1059–61. doi:10.1007/s003359900925. PMID 9880678. S2CID 792477.
• Miyashita A, Shimizu N, Endo N, et al. (1999). "Five different genes, Eif4a1, Cd68, Supl15h, Sox15 and Fxr2h, are clustered in a 40 kb region of mouse chromosome 11". Gene. 237 (1): 53–60. doi:10.1016/S0378-1119(99)00301-7. PMID 10524236.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.